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Major Depressive Disorder News

A man looks out a window
News
01/20/2026
Maria Mantas
A long-term extension study found that adjunctive vagus nerve stimulation (VNS) had a durable benefit in patients with treatment-resistant major depression over 24 months.
A long-term extension study found that adjunctive vagus nerve stimulation (VNS) had a durable benefit in patients with treatment-resistant major depression over 24 months.
A long-term extension study...
01/20/2026
Psych Congress Network
FDA building
News
01/12/2026
Maria Mantas
The US Food and Drug Administration has approved Proliv™Rx, a novel at-home neuromodulation therapy as adjunctive treatment for adults with major depressive disorder (MDD).
The US Food and Drug Administration has approved Proliv™Rx, a novel at-home neuromodulation therapy as adjunctive treatment for adults with major depressive disorder (MDD).
The US Food and Drug...
01/12/2026
Psych Congress Network
woman on a hill
News
01/09/2026
Maria Mantas
A new multi-site study suggests that while delay discounting is elevated in patients with remitted MDD, it neither changes after antidepressant medication discontinuation nor predicts subsequent depressive relapse.
A new multi-site study suggests that while delay discounting is elevated in patients with remitted MDD, it neither changes after antidepressant medication discontinuation nor predicts subsequent depressive relapse.
A new multi-site study suggests...
01/09/2026
Psych Congress Network
brain illustration
News
12/18/2025
Maria Mantas
An analysis from the multicenter PRONIA consortium reports that integrated peripheral inflammatory markers and whole-brain gray matter volumes can distinguish early-stage depression from psychosis.
An analysis from the multicenter PRONIA consortium reports that integrated peripheral inflammatory markers and whole-brain gray matter volumes can distinguish early-stage depression from psychosis.
An analysis from the multicenter...
12/18/2025
Psych Congress Network
FDA approval stamp
News
12/16/2025
Maria Mantas
The US Food and Drug Administration (FDA) has approved the first at-home transcranial direct current stimulation (tDCS) device for the treatment of moderate to severe major depressive disorder (MDD).
The US Food and Drug Administration (FDA) has approved the first at-home transcranial direct current stimulation (tDCS) device for the treatment of moderate to severe major depressive disorder (MDD).
The US Food and Drug...
12/16/2025
Psych Congress Network
laptop
News
11/11/2025
Maria Mantas
Adults with depression experienced similar treatment effects from asynchronous, message-based psychotherapy (MBP) and video-based psychotherapy (VBP), according to study results. 
Adults with depression experienced similar treatment effects from asynchronous, message-based psychotherapy (MBP) and video-based psychotherapy (VBP), according to study results. 
Adults with depression...
11/11/2025
Psych Congress Network
FDA approval stamp
News
11/07/2025
Maria Mantas
The US Food and Drug Administration (FDA) has approved lumateperone (CAPLYTA®) as an adjunctive therapy with antidepressants for the treatment of major depressive disorder (MDD) in adults.
The US Food and Drug Administration (FDA) has approved lumateperone (CAPLYTA®) as an adjunctive therapy with antidepressants for the treatment of major depressive disorder (MDD) in adults.
The US Food and Drug...
11/07/2025
Psych Congress Network
woman with depression
News
11/05/2025
Maria Mantas
A secondary analysis of the 2019 PANDA trial found that sertraline improved core symptoms of depression at as early as 2 weeks of treatment, suggesting a faster-acting benefit than previously thought.
A secondary analysis of the 2019 PANDA trial found that sertraline improved core symptoms of depression at as early as 2 weeks of treatment, suggesting a faster-acting benefit than previously thought.
A secondary analysis of the 2019...
11/05/2025
Psych Congress Network
black and white photo of a man
News
10/28/2025
Maria Mantas
Early exposure to lead, particularly in the third trimester of pregnancy, was associated with a higher risk of major depressive disorder and anxiety symptoms in later life, according to cohort study results.
Early exposure to lead, particularly in the third trimester of pregnancy, was associated with a higher risk of major depressive disorder and anxiety symptoms in later life, according to cohort study results.
Early exposure to lead,...
10/28/2025
Psych Congress Network
man looking out of a window
News
10/24/2025
Maria Mantas
According to a recent post hoc analysis, esmethadone (REL-1017) may be an effective adjunctive treatment for patients with major depressive disorder (MDD) and antidepressant tolerance/tachyphylaxis (AT). 
According to a recent post hoc analysis, esmethadone (REL-1017) may be an effective adjunctive treatment for patients with major depressive disorder (MDD) and antidepressant tolerance/tachyphylaxis (AT). 
According to a recent post hoc...
10/24/2025
Psych Congress Network